Human SPARC activation kit by CRISPRa

CAT#: GA104585

SPARC CRISPRa kit - CRISPR gene activation of human secreted protein acidic and cysteine rich

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPARC
• Locus ID: 6678
• Kit Components:

  GA104585G1, SPARC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104585G2, SPARC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104585G3, SPARC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001309444, NM_003118, NM_001309443
• Synonyms: BM-40; OI17; ON
• Summary: 'This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]'