Human SSB activation kit by CRISPRa

CAT#: GA104635

SSB CRISPRa kit - CRISPR gene activation of human small RNA binding exonuclease protection factor La

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SSB
• Locus ID: 6741
• Kit Components:

  GA104635G1, SSB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104635G2, SSB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104635G3, SSB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001294145, NM_003142
• Synonyms: La; La/SSB; LARP3
• Summary: 'The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]'