Human SSRP1 activation kit by CRISPRa

CAT#: GA104642

SSRP1 CRISPRa kit - CRISPR gene activation of human structure specific recognition protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SSRP1
• Locus ID: 6749
• Kit Components:

  GA104642G1, SSRP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104642G2, SSRP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104642G3, SSRP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003146
• Synonyms: FACT; FACT80; T160
• Summary: 'The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]'