Human STAT6 activation kit by CRISPRa

CAT#: GA104665

STAT6 CRISPRa kit - CRISPR gene activation of human signal transducer and activator of transcription 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STAT6
• Locus ID: 6778
• Kit Components:

  GA104665G1, STAT6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104665G2, STAT6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104665G3, STAT6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001178078, NM_001178079, NM_001178080, NM_001178081, NM_003153, NR_033659
• Synonyms: D12S1644; IL-4-STAT; STAT6B; STAT6C
• Summary: 'The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]'