Human Staufen (STAU1) activation kit by CRISPRa

CAT#: GA104667

STAU1 CRISPRa kit - CRISPR gene activation of human staufen double-stranded RNA binding protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STAU1
• Locus ID: 6780
• Kit Components:

  GA104667G1, Staufen gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104667G2, Staufen gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104667G3, Staufen gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001037328, NM_001319134, NM_001319135, NM_004602, NM_017452, NM_017453, NM_017454, NM_001322927, NM_001322928, NM_001322929, NM_001322930, NM_001322931, NM_001322932, NM_001322933
• Synonyms: PPP1R150; STAU
• Summary: 'Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]'