Human Stanniocalcin 1 (STC1) activation kit by CRISPRa

CAT#: GA104668

STC1 CRISPRa kit - CRISPR gene activation of human stanniocalcin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STC1
• Locus ID: 6781
• Kit Components:

  GA104668G1, Stanniocalcin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104668G2, Stanniocalcin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104668G3, Stanniocalcin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003155
• Synonyms: STC
• Summary: 'This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]'