Human LKB1 (STK11) activation kit by CRISPRa

CAT#: GA104679

STK11 CRISPRa kit - CRISPR gene activation of human serine/threonine kinase 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: STK11
• Locus ID: 6794
• Kit Components:

  GA104679G1, LKB1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104679G2, LKB1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104679G3, LKB1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000455
• Synonyms: hLKB1; LKB1; PJS
• Summary: 'This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]'