Human SURF1 activation kit by CRISPRa

CAT#: GA104702

SURF1 CRISPRa kit - CRISPR gene activation of human SURF1 cytochrome c oxidase assembly factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SURF1
• Locus ID: 6834
• Kit Components:

  GA104702G1, SURF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104702G2, SURF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104702G3, SURF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001280787, NM_003172
• Synonyms: CMT4K
• Summary: 'This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]'