Human SUV39H1 activation kit by CRISPRa

CAT#: GA104707

SUV39H1 CRISPRa kit - CRISPR gene activation of human suppressor of variegation 3-9 homolog 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SUV39H1
• Locus ID: 6839
• Kit Components:

  GA104707G1, SUV39H1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104707G2, SUV39H1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104707G3, SUV39H1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001282166, NM_003173
• Synonyms: H3-K9-HMTase 1; KMT1A; MG44; SUV39H
• Summary: 'This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]'