Human Neurokinin B (TAC3) activation kit by CRISPRa

CAT#: GA104725

TAC3 CRISPRa kit - CRISPR gene activation of human tachykinin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TAC3
• Locus ID: 6866
• Kit Components:

  GA104725G1, Neurokinin B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104725G2, Neurokinin B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104725G3, Neurokinin B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001006667, NM_001178054, NM_013251, NR_033654, NR_135164, NR_135165, NR_135166
• Synonyms: gamma tachykinin 3; neurokinin-B protein; neurokinin B-like protein; neurokinin beta; neuromedin K, neurokinin beta; NKB; NKB, NKNB, PRO1155, ZNEUROK1; NKNB; preprotachykinin B; PRO1155; tachykinin 3; ZNEUROK1
• Summary: 'This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]'