Human TCF7L2 activation kit by CRISPRa

CAT#: GA104784

TCF7L2 CRISPRa kit - CRISPR gene activation of human transcription factor 7 like 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TCF7L2
• Locus ID: 6934
• Kit Components:

  GA104784G1, TCF7L2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104784G2, TCF7L2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104784G3, TCF7L2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146274, NM_001146283, NM_001146284, NM_001146285, NM_001146286, NM_001198525, NM_001198526, NM_001198527, NM_001198528, NM_001198529, NM_001198530, NM_001198531, NM_030756, NM_001349870, NM_001349871, NM_001363501, NM_001367943
• Synonyms: TCF-4; TCF4
• Summary: 'This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]'