Human TRF1 (TERF1) activation kit by CRISPRa

CAT#: GA104823

TERF1 CRISPRa kit - CRISPR gene activation of human telomeric repeat binding factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TERF1
• Locus ID: 7013
• Kit Components:

  GA104823G1, TRF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104823G2, TRF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104823G3, TRF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003218, NM_017489
• Synonyms: hTRF1-AS; PIN2; t-TRF1; TRBF1; TRF; TRF1
• Summary: 'This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]'