Human TFPI activation kit by CRISPRa

CAT#: GA104842

TFPI CRISPRa kit - CRISPR gene activation of human tissue factor pathway inhibitor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TFPI
• Locus ID: 7035
• Kit Components:

  GA104842G1, TFPI gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104842G2, TFPI gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104842G3, TFPI gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001032281, NM_001318941, NM_006287, NM_001329239, NM_001329240, NM_001329241
• Synonyms: EPI; LACI; TFI; TFPI1
• Summary: 'This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]'