Human TGF beta 3 (TGFB3) activation kit by CRISPRa

CAT#: GA104850

TGFB3 CRISPRa kit - CRISPR gene activation of human transforming growth factor beta 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TGFB3
• Locus ID: 7043
• Kit Components:

  GA104850G1, TGF beta 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104850G2, TGF beta 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104850G3, TGF beta 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001329938, NM_001329939, NM_003239
• Synonyms: ARVD; ARVD1; LDS5; RNHF; TGF-beta3
• Summary: 'This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]'