Human Tyrosine Hydroxylase (TH) activation kit by CRISPRa

CAT#: GA104861

TH CRISPRa kit - CRISPR gene activation of human tyrosine hydroxylase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TH
• Locus ID: 7054
• Kit Components:

  GA104861G1, TH gRNA vector 1 in pCas-Guide-CRISPRa

  GA104861G2, TH gRNA vector 2 in pCas-Guide-CRISPRa

  GA104861G3, TH gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000360, NM_199292, NM_199293
• Synonyms: DYT5b; DYT14; TYH
• Summary: The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]