Human Thyroid Hormone Receptor alpha (THRA) activation kit by CRISPRa

CAT#: GA104870

THRA CRISPRa kit - CRISPR gene activation of human thyroid hormone receptor alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: THRA
• Locus ID: 7067
• Kit Components:

  GA104870G1, Thyroid Hormone Receptor alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104870G2, Thyroid Hormone Receptor alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104870G3, Thyroid Hormone Receptor alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001190918, NM_001190919, NM_003250, NM_199334
• Synonyms: AR7; c-ERBA-1; CHNG6; EAR7; ERB-T-1; ERBA; ERBA1; NR1A1; THRA1; THRA2
• Summary: 'The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]'