Human TIA1 activation kit by CRISPRa

CAT#: GA104875

TIA1 CRISPRa kit - CRISPR gene activation of human TIA1 cytotoxic granule associated RNA binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIA1
• Locus ID: 7072
• Kit Components:

  GA104875G1, TIA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104875G2, TIA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104875G3, TIA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022037, NM_022173, NM_001351508, NM_001351509, NM_001351510, NM_001351511, NM_001351512, NM_001351513, NM_001351514, NM_001351515, NM_001351516, NM_001351517, NM_001351518, NM_001351519, NM_001351520, NM_001351521, NM_001351522, NM_001351523, NM_001351524, NM_001351525, NR_147216, NR_147217, NR_147218, NR_147219, NR_147220, NR_147221, NR_147222, NR_147223, NR_147224, NR_147225, NR_147226, NR_147227, NR_147228, NR_147229, NR_147230, NR_147231, NR_147232
• Synonyms: TIA-1; WDM
• Summary: 'The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]'