Human TIMP1 activation kit by CRISPRa

CAT#: GA104879

TIMP1 CRISPRa kit - CRISPR gene activation of human TIMP metallopeptidase inhibitor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIMP1
• Locus ID: 7076
• Kit Components:

  GA104879G1, TIMP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104879G2, TIMP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104879G3, TIMP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003254
• Synonyms: CLGI; EPA; EPO; HCI; TIMP; TIMP-1
• Summary: 'This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]'