Human TIMP3 activation kit by CRISPRa

CAT#: GA104881

TIMP3 CRISPRa kit - CRISPR gene activation of human TIMP metallopeptidase inhibitor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TIMP3
• Locus ID: 7078
• Kit Components:

  GA104881G1, TIMP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104881G2, TIMP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104881G3, TIMP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000362
• Synonyms: HSMRK222; K222; K222TA2; SFD
• Summary: 'This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]'