Human ICAM5 activation kit by CRISPRa

CAT#: GA104888

ICAM5 CRISPRa kit - CRISPR gene activation of human intercellular adhesion molecule 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ICAM5
• Locus ID: 7087
• Kit Components:

  GA104888G1, ICAM5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104888G2, ICAM5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104888G3, ICAM5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003259
• Synonyms: TLCN; TLN
• Summary: 'The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]'