Human TLE3 activation kit by CRISPRa

CAT#: GA104891

TLE3 CRISPRa kit - CRISPR gene activation of human TLE family member 3, transcriptional corepressor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TLE3
• Locus ID: 7090
• Kit Components:

  GA104891G1, TLE3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104891G2, TLE3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104891G3, TLE3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001105192, NM_001282979, NM_001282980, NM_001282981, NM_001282982, NM_005078, NM_020908
• Synonyms: ESG; ESG3; GRG3; HsT18976
• Summary: 'This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]'