Human TSPAN6 activation kit by CRISPRa

CAT#: GA104906

TSPAN6 CRISPRa kit - CRISPR gene activation of human tetraspanin 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TSPAN6
• Locus ID: 7105
• Kit Components:

  GA104906G1, TSPAN6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104906G2, TSPAN6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104906G3, TSPAN6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278740, NM_001278741, NM_001278742, NM_001278743, NM_003270, N64145
• Synonyms: T245; TM4SF6; TSPAN-6
• Summary: 'The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]'