Human Claudin 5 (CLDN5) activation kit by CRISPRa

CAT#: GA104916

CLDN5 CRISPRa kit - CRISPR gene activation of human claudin 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLDN5
• Locus ID: 7122
• Kit Components:

  GA104916G1, Claudin 5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104916G2, Claudin 5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104916G3, Claudin 5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130861, NM_003277, NM_001363067, NM_001363066
• Synonyms: AWAL; BEC1; CPETRL1; TMVCF
• Summary: 'This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]'