Human TNFAIP3 activation kit by CRISPRa

CAT#: GA104922

TNFAIP3 CRISPRa kit - CRISPR gene activation of human TNF alpha induced protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFAIP3
• Locus ID: 7128
• Kit Components:

  GA104922G1, TNFAIP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104922G2, TNFAIP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104922G3, TNFAIP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001270507, NM_001270508, NM_006290
• Synonyms: A20; AISBL; OTUD7C; TNFA1P2
• Summary: 'This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]'