Human TSG6 (TNFAIP6) activation kit by CRISPRa

CAT#: GA104923

TNFAIP6 CRISPRa kit - CRISPR gene activation of human TNF alpha induced protein 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFAIP6
• Locus ID: 7130
• Kit Components:

  GA104923G1, TSG6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104923G2, TSG6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104923G3, TSG6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007115
• Synonyms: TSG-6; TSG6
• Summary: 'The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]'