Human Topoisomerase I (TOP1) activation kit by CRISPRa

CAT#: GA104938

TOP1 CRISPRa kit - CRISPR gene activation of human DNA topoisomerase I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TOP1
• Locus ID: 7150
• Kit Components:

  GA104938G1, TOP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA104938G2, TOP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA104938G3, TOP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003286
• Synonyms: TOPI
• Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]