Human p73 (TP73) activation kit by CRISPRa

CAT#: GA104945

TP73 CRISPRa kit - CRISPR gene activation of human tumor protein p73

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TP73
• Locus ID: 7161
• Kit Components:

  GA104945G1, p73 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104945G2, p73 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104945G3, p73 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001126240, NM_001126241, NM_001126242, NM_001204184, NM_001204185, NM_001204186, NM_001204187, NM_001204188, NM_001204189, NM_001204190, NM_001204191, NM_001204192, NM_005427
• Synonyms: P73
• Summary: 'This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]'