Human Tropomyosin 2 (TPM2) activation kit by CRISPRa

CAT#: GA104953

TPM2 CRISPRa kit - CRISPR gene activation of human tropomyosin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPM2
• Locus ID: 7169
• Kit Components:

  GA104953G1, Tropomyosin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104953G2, Tropomyosin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104953G3, Tropomyosin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145822, NM_001301226, NM_001301227, NM_003289, NM_213674
• Synonyms: AMCD1; arthrogryposis multiplex congenital, distal, type 1; DA1; DA2B; NEM4; OTTHUMP00000021357; TMSB; tropomyosin 2 (beta)
• Summary: 'This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]'