Tropomyosin 2 (TPM2) Rabbit Polyclonal Antibody

CAT#: TA308017

Rabbit polyclonal antibody to Tropomyosin 2 (tropomyosin 2 (beta))

Product Images

Sample (30 ug of whole cell lysate). A: HeLa. 10% SDS PAGE. TA308017 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using Tropomyosin 2 (TA308017) antibody at 1:100 dilution.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 234 of Tropomyosin 2 (Uniprot ID#P07951)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 33 kDa
• Gene Name: tropomyosin 2 (beta)
• Database Link:
  NP_001139294
  Entrez Gene 22004 MouseEntrez Gene 500450 RatEntrez Gene 7169 Human
  UniProt ID P07951
• Background: This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: AMCD1; arthrogryposis multiplex congenital; DA1; DA2B; distal; NEM4; OTTHUMP00000021357; TMSB; tropomyosin 2 (beta); type 1
• Note: Seq homology of immunogen across species: Mouse (86%), Rat (99%), Bovine (92%), Xenopus tropicalis (85%)

Reference Data

• Protein Pathways: Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)