Human TCTP (TPT1) activation kit by CRISPRa

CAT#: GA104961

TPT1 CRISPRa kit - CRISPR gene activation of human tumor protein, translationally-controlled 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPT1
• Locus ID: 7178
• Kit Components:

  GA104961G1, TCTP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104961G2, TCTP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104961G3, TCTP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286272, NM_001286273, NM_003295
• Synonyms: HRF; p02; p23; TCTP
• Summary: 'This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]'