Human NR2C2 activation kit by CRISPRa

CAT#: GA104965

NR2C2 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 2 group C member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NR2C2
• Locus ID: 7182
• Kit Components:

  GA104965G1, NR2C2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104965G2, NR2C2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104965G3, NR2C2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001291694, NM_003298
• Synonyms: TAK1; TR4
• Summary: 'This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]'