Human TRAF3 activation kit by CRISPRa

CAT#: GA104969

TRAF3 CRISPRa kit - CRISPR gene activation of human TNF receptor associated factor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRAF3
• Locus ID: 7187
• Kit Components:

  GA104969G1, TRAF3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104969G2, TRAF3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104969G3, TRAF3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199427, NM_003300, NM_145725, NM_145726
• Synonyms: CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1
• Summary: 'The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]'