TRAF3 Rabbit Polyclonal Antibody

CAT#: TA306249

Rabbit Polyclonal TRAF3 Antibody

Product Images

Western blot analysis of TRAF3 in 3T3 cell lysate with TRAF3 antibody at (A) 1, and (B) 2 ug/ml.

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  Immunofluorescence of TRAF3 in 3T3 cells with TRAF3 antibody at 2 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 2 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRAF3 antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human TRAF3.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TNF receptor associated factor 3
• Database Link:
  NP_003291
  Entrez Gene 22031 MouseEntrez Gene 7187 Human
  UniProt ID Q13114
• Background: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kappaB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR (5).
• Synonyms: CAP-1; CAP1; CD40bp; CRAF1; IIAE5; LAP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, Toll-like receptor signaling pathway