Human TRPC4 activation kit by CRISPRa

CAT#: GA104980

TRPC4 CRISPRa kit - CRISPR gene activation of human transient receptor potential cation channel subfamily C member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRPC4
• Locus ID: 7223
• Kit Components:

  GA104980G1, TRPC4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104980G2, TRPC4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104980G3, TRPC4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135955, NM_001135956, NM_001135957, NM_001135958, NM_003306, NM_016179, NM_001354799, NM_001354806
• Synonyms: HTRP-4; HTRP4; TRP4
• Summary: 'This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]'