Human Translin (TSN) activation kit by CRISPRa

CAT#: GA104985

TSN CRISPRa kit - CRISPR gene activation of human translin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TSN
• Locus ID: 7247
• Kit Components:

  GA104985G1, Translin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104985G2, Translin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104985G3, Translin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001261401, NM_004622, NR_048556, NR_048557, NR_048558, NR_048559
• Synonyms: BCLF-1; C3PO; RCHF1; REHF-1; TBRBP; TRSLN
• Summary: 'This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]'