Human Mps1 (TTK) activation kit by CRISPRa

CAT#: GA105006

TTK CRISPRa kit - CRISPR gene activation of human TTK protein kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TTK
• Locus ID: 7272
• Kit Components:

  GA105006G1, Mps1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105006G2, Mps1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105006G3, Mps1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166691, NM_003318
• Synonyms: CT96; ESK; MPH1; MPS1; MPS1L1; PYT
• Summary: 'This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]'