Human UBE2D3 activation kit by CRISPRa

CAT#: GA105043

UBE2D3 CRISPRa kit - CRISPR gene activation of human ubiquitin conjugating enzyme E2 D3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBE2D3
• Locus ID: 7323
• Kit Components:

  GA105043G1, UBE2D3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105043G2, UBE2D3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105043G3, UBE2D3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001300795, NM_003340, NM_181886, NM_181887, NM_181888, NM_181889, NM_181890, NM_181891, NM_181892, NM_181893
• Synonyms: E2(17)KB3; UBC4/5; UBCH5C
• Summary: 'The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. [provided by RefSeq, Jan 2017]'