Human UBE2L3 activation kit by CRISPRa

CAT#: GA105050

UBE2L3 CRISPRa kit - CRISPR gene activation of human ubiquitin conjugating enzyme E2 L3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UBE2L3
• Locus ID: 7332
• Kit Components:

  GA105050G1, UBE2L3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105050G2, UBE2L3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105050G3, UBE2L3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256355, NM_001256356, NM_003347, NM_198157, NR_028436, NR_028437, NR_046082
• Synonyms: E2-F1; L-UBC; UBCH7; UbcM4
• Summary: 'The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]'