Human UQCRB activation kit by CRISPRa

CAT#: GA105087

UQCRB CRISPRa kit - CRISPR gene activation of human ubiquinol-cytochrome c reductase binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: UQCRB
• Locus ID: 7381
• Kit Components:

  GA105087G1, UQCRB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105087G2, UQCRB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105087G3, UQCRB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001199975, NM_001254752, NM_006294, NR_045639
• Synonyms: MC3DN3; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6; UQPC
• Summary: 'This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]'