Human Vinculin (VCL) activation kit by CRISPRa

CAT#: GA105109

VCL CRISPRa kit - CRISPR gene activation of human vinculin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VCL
• Locus ID: 7414
• Kit Components:

  GA105109G1, Vinculin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105109G2, Vinculin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105109G3, Vinculin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003373, NM_014000
• Synonyms: CMD1W; CMH15; HEL114; MV; MVCL
• Summary: 'Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]'