Human VEGFB activation kit by CRISPRa

CAT#: GA105116

VEGFB CRISPRa kit - CRISPR gene activation of human vascular endothelial growth factor B

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VEGFB
• Locus ID: 7423
• Kit Components:

  GA105116G1, VEGFB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105116G2, VEGFB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105116G3, VEGFB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243733, NM_003377
• Synonyms: VEGFL; VRF
• Summary: 'This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]'