Human Vimentin (VIM) activation kit by CRISPRa

CAT#: GA105122

VIM CRISPRa kit - CRISPR gene activation of human vimentin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: VIM
• Locus ID: 7431
• Kit Components:

  GA105122G1, Vimentin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105122G2, Vimentin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105122G3, Vimentin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003380
• Synonyms: CTRCT30; HEL113
• Summary: 'This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]'