Human XPA activation kit by CRISPRa

CAT#: GA105168

XPA CRISPRa kit - CRISPR gene activation of human XPA, DNA damage recognition and repair factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XPA
• Locus ID: 7507
• Kit Components:

  GA105168G1, XPA gRNA vector 1 in pCas-Guide-CRISPRa

  GA105168G2, XPA gRNA vector 2 in pCas-Guide-CRISPRa

  GA105168G3, XPA gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000380, NR_027302, NM_001354975, NR_149091, NR_149092, NR_149093, NR_149094
• Synonyms: XP1; XPAC
• Summary: This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]