Human XPC activation kit by CRISPRa

CAT#: GA105169

XPC CRISPRa kit - CRISPR gene activation of human XPC complex subunit, DNA damage recognition and repair factor

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XPC
• Locus ID: 7508
• Kit Components:

  GA105169G1, XPC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105169G2, XPC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105169G3, XPC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145769, NM_004628, NR_027299, NM_001354726, NM_001354727, NM_001354729, NM_001354730, NR_148950, NR_148951
• Synonyms: RAD4; XP3; XPCC
• Summary: 'The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]'