Human XRCC4 activation kit by CRISPRa

CAT#: GA105176

XRCC4 CRISPRa kit - CRISPR gene activation of human X-ray repair cross complementing 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XRCC4
• Locus ID: 7518
• Kit Components:

  GA105176G1, XRCC4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105176G2, XRCC4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105176G3, XRCC4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318012, NM_001318013, NM_003401, NM_022406, NM_022550
• Synonyms: SSMED
• Summary: 'The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternate transcript variants such as NM_022406 are unlikely to be expressed in some individuals due to a polymorphism (rs1805377) in the last splice acceptor site. [provided by RefSeq, Oct 2019]'