Human ZNF148 activation kit by CRISPRa

CAT#: GA105266

ZNF148 CRISPRa kit - CRISPR gene activation of human zinc finger protein 148

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ZNF148
• Locus ID: 7707
• Kit Components:

  GA105266G1, ZNF148 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105266G2, ZNF148 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105266G3, ZNF148 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021964, NM_001348424, NM_001348425, NM_001348426, NM_001348427, NM_001348428, NM_001348429, NM_001348430, NM_001348431, NM_001348432, NM_001348433, NM_001348434, NM_001348436
• Synonyms: BERF-1; BFCOL1; HT-BETA; pHZ-52; ZBP-89; ZFP148
• Summary: 'The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]'