Human SLC30A4 activation kit by CRISPRa

CAT#: GA105311

SLC30A4 CRISPRa kit - CRISPR gene activation of human solute carrier family 30 member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SLC30A4
• Locus ID: 7782
• Kit Components:

  GA105311G1, SLC30A4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105311G2, SLC30A4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105311G3, SLC30A4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321036, NM_013309
• Synonyms: znT-4; ZNT4
• Summary: Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]). [supplied by OMIM, Mar 2008]