Human MAP3K12 activation kit by CRISPRa

CAT#: GA105314

MAP3K12 CRISPRa kit - CRISPR gene activation of human mitogen-activated protein kinase kinase kinase 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MAP3K12
• Locus ID: 7786
• Kit Components:

  GA105314G1, MAP3K12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105314G2, MAP3K12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105314G3, MAP3K12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001193511, NM_006301
• Synonyms: DLK; MEKK12; MUK; ZPK; ZPKP1
• Summary: This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2010]