Human RIZ1 (PRDM2) activation kit by CRISPRa

CAT#: GA105318

PRDM2 CRISPRa kit - CRISPR gene activation of human PR/SET domain 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PRDM2
• Locus ID: 7799
• Kit Components:

  GA105318G1, PRDM2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105318G2, PRDM2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105318G3, PRDM2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001007257, NM_001135610, NM_012231, NM_015866
• Synonyms: HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
• Summary: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]