Human GCS1 (MOGS) activation kit by CRISPRa

CAT#: GA105331

MOGS CRISPRa kit - CRISPR gene activation of human mannosyl-oligosaccharide glucosidase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MOGS
• Locus ID: 7841
• Kit Components:

  GA105331G1, MOGS gRNA vector 1 in pCas-Guide-CRISPRa

  GA105331G2, MOGS gRNA vector 2 in pCas-Guide-CRISPRa

  GA105331G3, MOGS gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001146158, NM_006302
• Synonyms: CDG2B; CWH41; DER7; GCS1
• Summary: This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]